Preheat air fryer according to manufacturer's instructions to 375°. Spray air fryer basket with vegetable-based cooking spray.
In small bowl, combine cream cheese, sour cream, bacon, panko bread crumbs, green onions, cayenne pepper and garlic powder. Mix well until thoroughly combined.
Use a spatula or a small spoon to scoop filling into jalapeno peppers.
Working in batches, arrange stuffed jalapeno poppers in prepared air fryer basket in a single layer (see image above) and cook for 8 - 10 minutes, or until peppers are soft and tops are golden brown.
Remove jalapeno poppers from air fryer and serve immediately.